Assay Detail
Binding
CHEMBL1012732
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Inhibition of p38alpha MAP kinase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Role of the hydrogen bonding heteroatom-Lys53 interaction between the p38alpha mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.24 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63135 | — | — | 1 | 7.10 |
| CHEMBL66802 | — | — | 1 | 6.38 |
| CHEMBL88925 | — | — | 1 | 6.28 |
| CHEMBL155687 | — | — | 1 | 6.17 |
| CHEMBL483614 | — | — | 1 | 6.13 |
| CHEMBL507086 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63135 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL66802 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL88925 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL155687 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL483614 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL507086 | — | IC50 | = | 4050.0 | nM | 5.39 |