Assay Detail
Functional
CHEMBL1012844
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Vasodilation activity in Wistar rat aorta assessed as relaxation of phenylephrine-induced contraction
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Edaravone derivatives containing NO-donor functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.21 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495512 | — | — | 1 | 8.02 |
| CHEMBL363325 | — | — | 1 | 7.92 |
| CHEMBL510434 | — | — | 1 | 7.64 |
| CHEMBL497168 | — | — | 1 | 7.11 |
| CHEMBL449800 | — | — | 1 | 6.18 |
| CHEMBL522048 | — | — | 1 | 6.17 |
| CHEMBL495719 | — | — | 1 | 6.01 |
| CHEMBL495513 | — | — | 1 | 5.96 |
| CHEMBL458087 | — | — | 1 | 5.85 |
| CHEMBL523928 | — | — | 1 | 5.55 |
| CHEMBL502722 | — | — | 1 | 5.41 |
| CHEMBL456685 | — | — | 1 | 5.25 |
| CHEMBL509035 | — | — | 1 | 5.02 |
| CHEMBL497994 | — | — | 1 | 4.85 |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | - |
| CHEMBL219768 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495512 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL363325 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL510434 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL497168 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL449800 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL522048 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL495719 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL495513 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL458087 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL523928 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL502722 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL456685 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL509035 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL497994 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL290916 | EDARAVONE | EC50 | - | — | - | |
| CHEMBL219768 | — | EC50 | - | — | - |