Assay Detail
Functional
CHEMBL1012846
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Antioxidant activity against Fe2SO4/ascorbate-induced lipid peroxidation in Wistar rat liver microsomal membrane by TBARS assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 2 — Organism |
| Curated By | Autocuration |
Publication
Edaravone derivatives containing NO-donor functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.31 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497994 | — | — | 1 | 5.89 |
| CHEMBL495719 | — | — | 1 | 5.68 |
| CHEMBL522048 | — | — | 1 | 5.54 |
| CHEMBL495513 | — | — | 1 | 5.47 |
| CHEMBL497168 | — | — | 1 | 5.42 |
| CHEMBL510434 | — | — | 1 | 5.24 |
| CHEMBL523928 | — | — | 1 | 5.10 |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | 4.77 |
| CHEMBL219768 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497994 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL495719 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL522048 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL495513 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL497168 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL510434 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL523928 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL290916 | EDARAVONE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL219768 | — | IC50 | = | 20000.0 | nM | 4.70 |