Assay Detail
Functional
CHEMBL1013116
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha release in human whole blood
95
Total Activities
95
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 95 | 5.25 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481765 | — | — | 1 | 6.78 |
| CHEMBL480962 | — | — | 1 | 6.70 |
| CHEMBL480958 | — | — | 1 | 6.62 |
| CHEMBL493669 | — | — | 1 | 6.46 |
| CHEMBL482086 | — | — | 1 | 6.44 |
| CHEMBL516607 | — | — | 1 | 6.41 |
| CHEMBL521091 | — | — | 1 | 6.38 |
| CHEMBL519621 | — | — | 1 | 6.36 |
| CHEMBL521250 | — | — | 1 | 6.36 |
| CHEMBL482087 | — | — | 1 | 6.34 |
| CHEMBL480952 | — | — | 1 | 6.29 |
| CHEMBL516460 | — | — | 1 | 6.24 |
| CHEMBL481919 | — | — | 1 | 6.21 |
| CHEMBL494666 | — | — | 1 | 6.17 |
| CHEMBL481100 | — | — | 1 | 6.17 |
| CHEMBL481766 | — | — | 1 | 6.16 |
| CHEMBL481116 | — | — | 1 | 5.97 |
| CHEMBL111456 | — | — | 1 | 5.96 |
| CHEMBL481952 | — | — | 1 | 5.78 |
| CHEMBL481749 | — | — | 1 | 5.78 |
| CHEMBL479991 | — | — | 1 | 5.77 |
| CHEMBL480951 | — | — | 1 | 5.69 |
| CHEMBL10 | SB-203580 | — | 1 | 5.64 |
| CHEMBL479810 | — | — | 1 | 5.61 |
| CHEMBL494871 | — | — | 1 | 5.57 |
| CHEMBL494879 | — | — | 1 | 5.55 |
| CHEMBL482111 | — | — | 1 | 5.53 |
| CHEMBL324977 | — | — | 1 | 5.52 |
| CHEMBL481913 | — | — | 1 | 5.48 |
| CHEMBL481943 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481765 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL480962 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL480958 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL493669 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL482086 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL516607 | — | IC50 | = | 386.0 | nM | 6.41 |
| CHEMBL521091 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL519621 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL521250 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL482087 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL480952 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL516460 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL481919 | — | IC50 | = | 622.0 | nM | 6.21 |
| CHEMBL481100 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL494666 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL481766 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL481116 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL111456 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL481952 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL481749 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL479991 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL480951 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL10 | SB-203580 | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL479810 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL494871 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL494879 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL482111 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL324977 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL481913 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL481943 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL481750 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL523880 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL518964 | — | IC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL481883 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL111364 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL481926 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL482279 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL452471 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL519628 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL109352 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL481918 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL481882 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL481944 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL481912 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL506320 | — | IC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL481950 | — | IC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL519624 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL113419 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL479998 | — | IC50 | = | 9860.0 | nM | 5.01 |
| CHEMBL482112 | — | IC50 | = | 9850.0 | nM | 5.01 |