Assay Detail
Functional
CHEMBL1013117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL1-beta release in human whole blood
80
Total Activities
80
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 80 | 5.53 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113419 | — | — | 1 | 7.36 |
| CHEMBL109352 | — | — | 1 | 7.10 |
| CHEMBL482087 | — | — | 1 | 6.87 |
| CHEMBL480952 | — | — | 1 | 6.60 |
| CHEMBL111456 | — | — | 1 | 6.42 |
| CHEMBL481765 | — | — | 1 | 6.20 |
| CHEMBL482279 | — | — | 1 | 5.89 |
| CHEMBL482111 | — | — | 1 | 5.87 |
| CHEMBL521091 | — | — | 1 | 5.72 |
| CHEMBL10 | SB-203580 | — | 1 | 5.70 |
| CHEMBL493669 | — | — | 1 | 5.62 |
| CHEMBL481919 | — | — | 1 | 5.56 |
| CHEMBL324977 | — | — | 1 | 5.39 |
| CHEMBL111364 | — | — | 1 | 5.36 |
| CHEMBL518964 | — | — | 1 | 5.12 |
| CHEMBL494666 | — | — | 1 | 5.12 |
| CHEMBL523880 | — | — | 1 | 5.00 |
| CHEMBL481706 | — | — | 1 | 4.99 |
| CHEMBL494879 | — | — | 1 | 4.79 |
| CHEMBL519617 | — | — | 1 | 4.63 |
| CHEMBL480957 | — | — | 1 | 4.56 |
| CHEMBL494901 | — | — | 1 | 4.46 |
| CHEMBL481965 | — | — | 1 | 4.23 |
| CHEMBL516761 | — | — | 1 | 4.21 |
| CHEMBL109028 | — | — | 1 | - |
| CHEMBL481116 | — | — | 1 | - |
| CHEMBL452471 | — | — | 1 | - |
| CHEMBL479416 | — | — | 1 | - |
| CHEMBL481316 | — | — | 1 | - |
| CHEMBL481315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113419 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL109352 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL482087 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL480952 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL111456 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL481765 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL482279 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL482111 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL521091 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL10 | SB-203580 | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL493669 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL481919 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL324977 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL111364 | — | IC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL494666 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL518964 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL523880 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL481706 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL494879 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL519617 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL480957 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL494901 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL481965 | — | IC50 | = | 59300.0 | nM | 4.23 |
| CHEMBL516761 | — | IC50 | = | 61300.0 | nM | 4.21 |
| CHEMBL480956 | — | IC50 | - | — | - | |
| CHEMBL481698 | — | IC50 | - | — | - | |
| CHEMBL522362 | — | IC50 | - | — | - | |
| CHEMBL494665 | — | IC50 | - | — | - | |
| CHEMBL524015 | — | IC50 | - | — | - | |
| CHEMBL109383 | — | IC50 | - | — | - | |
| CHEMBL521692 | — | IC50 | - | — | - | |
| CHEMBL110262 | — | IC50 | - | — | - | |
| CHEMBL494902 | — | IC50 | - | — | - | |
| CHEMBL481945 | — | IC50 | - | — | - | |
| CHEMBL113060 | — | IC50 | - | — | - | |
| CHEMBL111403 | — | IC50 | - | — | - | |
| CHEMBL481751 | — | IC50 | - | — | - | |
| CHEMBL479985 | — | IC50 | - | — | - | |
| CHEMBL494871 | — | IC50 | - | — | - | |
| CHEMBL516607 | — | IC50 | - | — | - | |
| CHEMBL480962 | — | IC50 | - | — | - | |
| CHEMBL481100 | — | IC50 | - | — | - | |
| CHEMBL493870 | — | IC50 | - | — | - | |
| CHEMBL518962 | — | IC50 | - | — | - | |
| CHEMBL481315 | — | IC50 | - | — | - | |
| CHEMBL481316 | — | IC50 | - | — | - | |
| CHEMBL479416 | — | IC50 | - | — | - | |
| CHEMBL452471 | — | IC50 | - | — | - | |
| CHEMBL481116 | — | IC50 | - | — | - | |
| CHEMBL109028 | — | IC50 | - | — | - |