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Assay Detail

CHEMBL1013488

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Binding
Inhibition of angiotensin-converting enzyme in whole blood by HPLC
ChEMBL ↗
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Blood
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Angiotensin-converting enzyme (CHEMBL1808) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors.
Enomoto H, Morikawa Y, Miyake Y, Tsuji F, Mizuchi M, Suhara H, Fujimura K, Horiuchi M, Ban M.
Bioorg Med Chem Lett (2009) 19 : 442 -446
PubMed 19042128 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 6.47 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL511184 — — 1 7.68
CHEMBL451209 — — 1 7.47
CHEMBL467755 — — 1 7.00
CHEMBL511344 — — 1 7.00
CHEMBL463320 — — 1 6.89
CHEMBL459959 — — 1 6.85
CHEMBL458238 — — 1 6.70
CHEMBL461021 — — 1 6.68
CHEMBL459960 — — 1 6.62
CHEMBL444474 — — 1 6.60
CHEMBL456723 — — 1 6.58
CHEMBL515834 — — 1 6.58
CHEMBL513671 — — 1 6.55
CHEMBL463520 — — 1 6.55
CHEMBL457796 — — 1 6.52
CHEMBL458237 — — 1 6.52
CHEMBL511849 — — 1 6.52
CHEMBL461022 — — 1 6.52
CHEMBL456278 — — 1 6.50
CHEMBL458447 — — 1 6.47
CHEMBL457571 — — 1 6.47
CHEMBL459961 — — 1 6.47
CHEMBL514268 — — 1 6.43
CHEMBL458450 — — 1 6.38
CHEMBL458451 — — 1 6.37
CHEMBL457317 — — 1 6.28
CHEMBL516325 — — 1 5.77
CHEMBL456045 — — 1 5.52
CHEMBL505067 — — 1 5.44
CHEMBL512941 — — 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL511184 — IC50 = 21.0 nM 7.68
CHEMBL451209 — IC50 = 34.0 nM 7.47
CHEMBL467755 — IC50 = 100.0 nM 7.00
CHEMBL511344 — IC50 = 100.0 nM 7.00
CHEMBL463320 — IC50 = 130.0 nM 6.89
CHEMBL459959 — IC50 = 140.0 nM 6.85
CHEMBL458238 — IC50 = 200.0 nM 6.70
CHEMBL461021 — IC50 = 210.0 nM 6.68
CHEMBL459960 — IC50 = 240.0 nM 6.62
CHEMBL444474 — IC50 = 250.0 nM 6.60
CHEMBL456723 — IC50 = 260.0 nM 6.58
CHEMBL515834 — IC50 = 260.0 nM 6.58
CHEMBL513671 — IC50 = 280.0 nM 6.55
CHEMBL463520 — IC50 = 280.0 nM 6.55
CHEMBL511849 — IC50 = 300.0 nM 6.52
CHEMBL458237 — IC50 = 300.0 nM 6.52
CHEMBL461022 — IC50 = 300.0 nM 6.52
CHEMBL457796 — IC50 = 300.0 nM 6.52
CHEMBL456278 — IC50 = 320.0 nM 6.50
CHEMBL458447 — IC50 = 340.0 nM 6.47
CHEMBL457571 — IC50 = 340.0 nM 6.47
CHEMBL459961 — IC50 = 340.0 nM 6.47
CHEMBL514268 — IC50 = 370.0 nM 6.43
CHEMBL458450 — IC50 = 420.0 nM 6.38
CHEMBL458451 — IC50 = 430.0 nM 6.37
CHEMBL457317 — IC50 = 520.0 nM 6.28
CHEMBL516325 — IC50 = 1700.0 nM 5.77
CHEMBL456045 — IC50 = 3000.0 nM 5.52
CHEMBL505067 — IC50 = 3600.0 nM 5.44
CHEMBL512941 — IC50 = 4000.0 nM 5.40
CHEMBL457795 — IC50 = 4600.0 nM 5.34
CHEMBL511339 — IC50 > 10000.0 nM -
CHEMBL456044 — IC50 > 10000.0 nM -