Assay Detail
Functional
CHEMBL1013494
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Antiviral activity against HPMPA-resistant HCMV AD169 clone 2 mutant infected in HEL cells assessed as inhibition of virus-induced cytopathicity
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.70 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 6.26 |
| CHEMBL61733 | PMEDAP | — | 1 | 6.09 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.00 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.92 |
| CHEMBL286534 | — | — | 1 | 5.72 |
| CHEMBL461899 | — | — | 1 | 5.00 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL61733 | PMEDAP | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL286534 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL461899 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL666 | FOSCARNET | EC50 | = | 13000.0 | nM | 4.89 |