Assay Detail
Functional
CHEMBL1013496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HCMV AD169 infected in HEL cells assessed as inhibition of virus-induced cytopathicity
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.69 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 7.12 |
| CHEMBL286534 | — | — | 1 | 6.77 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.16 |
| CHEMBL61733 | PMEDAP | — | 1 | 5.08 |
| CHEMBL461899 | — | — | 1 | 4.96 |
| CHEMBL666 | FOSCARNET | 4.0 | 1 | 4.89 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL286534 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL61733 | PMEDAP | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL461899 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL666 | FOSCARNET | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 15000.0 | nM | 4.82 |