Assay Detail
Binding
CHEMBL1014228
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Binding affinity to EP1 receptor
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of GSK345931A: An EP(1) receptor antagonist with efficacy in preclinical models of inflammatory pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.46 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL516324 | — | — | 1 | 8.70 |
| CHEMBL514574 | — | — | 1 | 8.40 |
| CHEMBL458452 | — | — | 1 | 8.40 |
| CHEMBL457142 | — | — | 1 | 8.30 |
| CHEMBL456496 | — | — | 1 | 8.20 |
| CHEMBL515981 | — | — | 1 | 8.00 |
| CHEMBL458448 | — | — | 1 | 8.00 |
| CHEMBL456495 | — | — | 1 | 8.00 |
| CHEMBL466549 | — | — | 1 | 7.90 |
| CHEMBL467510 | — | — | 1 | 7.80 |
| CHEMBL516787 | — | — | 1 | 7.70 |
| CHEMBL467579 | — | — | 1 | 7.70 |
| CHEMBL456707 | — | — | 1 | 7.70 |
| CHEMBL459537 | — | — | 1 | 7.40 |
| CHEMBL467578 | — | — | 1 | 7.30 |
| CHEMBL207174 | — | — | 1 | 7.30 |
| CHEMBL514425 | — | — | 1 | 7.20 |
| CHEMBL512617 | — | — | 1 | 7.20 |
| CHEMBL459091 | — | — | 1 | 7.10 |
| CHEMBL499155 | — | — | 1 | 7.00 |
| CHEMBL458008 | — | — | 1 | 7.00 |
| CHEMBL457797 | — | — | 1 | 6.90 |
| CHEMBL458858 | — | — | 1 | 6.80 |
| CHEMBL456679 | — | — | 1 | 6.60 |
| CHEMBL460168 | — | — | 1 | 6.50 |
| CHEMBL515697 | — | — | 1 | 6.30 |
| CHEMBL456919 | — | — | 1 | 6.10 |
| CHEMBL462294 | — | — | 1 | - |
| CHEMBL460169 | — | — | 1 | - |
| CHEMBL456706 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL516324 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL514574 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL458452 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL457142 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL456496 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL515981 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL458448 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL456495 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL466549 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL467510 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL516787 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL467579 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL456707 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL459537 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL467578 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL207174 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL514425 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL512617 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL459091 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL499155 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL458008 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL457797 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL458858 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL456679 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL460168 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL515697 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL456919 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL462294 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL460169 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL456706 | — | IC50 | > | 1000.0 | nM | - |