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Assay Detail

CHEMBL1014433

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Binding
Inhibition of Plasmodium vivax FPPS expressed in Escherichia coli BL21 by spectrophotometric assay
ChEMBL ↗
52
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium vivax
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data.
Mukkamala D, No JH, Cass LM, Chang TK, Oldfield E.
J Med Chem (2008) 51 : 7827 -7833
PubMed 19053772 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 52 5.98 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL301244 — — 2 6.40
CHEMBL54537 — — 2 6.35
CHEMBL52251 (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID — 2 6.31
CHEMBL923 RISEDRONIC ACID 4.0 2 6.23
CHEMBL56073 — — 2 6.21
CHEMBL196631 — — 2 6.20
CHEMBL56556 — — 2 6.20
CHEMBL198126 — — 2 6.20
CHEMBL195034 — — 2 6.20
CHEMBL608526 — — 2 6.20
CHEMBL55264 — — 2 6.20
CHEMBL100831 — — 2 6.15
CHEMBL54004 — — 2 6.15
CHEMBL52761 — — 2 6.11
CHEMBL294192 — — 2 6.10
CHEMBL4303669 ZOLEDRONIC ACID 4.0 2 6.10
CHEMBL371456 — — 2 6.10
CHEMBL374042 — — 2 6.10
CHEMBL434024 — — 2 6.05
CHEMBL54714 — — 2 6.04
CHEMBL997 IBANDRONIC ACID 4.0 2 6.04
CHEMBL55359 — — 2 5.92
CHEMBL127588 — — 2 5.64
CHEMBL55810 — — 2 5.40
CHEMBL417549 (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID — 2 5.30
CHEMBL267880 — — 2 4.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL301244 — IC50 = 400.0 nM 6.40
CHEMBL301244 — IC50 = 398.11 nM 6.40
CHEMBL54537 — IC50 = 450.0 nM 6.35
CHEMBL52251 (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 490.0 nM 6.31
CHEMBL52251 (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 501.19 nM 6.30
CHEMBL54537 — IC50 = 501.19 nM 6.30
CHEMBL923 RISEDRONIC ACID IC50 = 590.0 nM 6.23
CHEMBL56073 — IC50 = 610.0 nM 6.21
CHEMBL923 RISEDRONIC ACID IC50 = 630.96 nM 6.20
CHEMBL55264 — IC50 = 630.96 nM 6.20
CHEMBL56073 — IC50 = 630.96 nM 6.20
CHEMBL196631 — IC50 = 630.96 nM 6.20
CHEMBL195034 — IC50 = 630.96 nM 6.20
CHEMBL195034 — IC50 = 630.0 nM 6.20
CHEMBL198126 — IC50 = 630.96 nM 6.20
CHEMBL608526 — IC50 = 630.96 nM 6.20
CHEMBL198126 — IC50 = 630.0 nM 6.20
CHEMBL56556 — IC50 = 630.96 nM 6.20
CHEMBL55264 — IC50 = 630.0 nM 6.20
CHEMBL608526 — IC50 = 640.0 nM 6.19
CHEMBL196631 — IC50 = 680.0 nM 6.17
CHEMBL56556 — IC50 = 690.0 nM 6.16
CHEMBL100831 — IC50 = 710.0 nM 6.15
CHEMBL54004 — IC50 = 710.0 nM 6.15
CHEMBL52761 — IC50 = 780.0 nM 6.11
CHEMBL294192 — IC50 = 794.33 nM 6.10
CHEMBL54004 — IC50 = 794.33 nM 6.10
CHEMBL374042 — IC50 = 794.33 nM 6.10
CHEMBL4303669 ZOLEDRONIC ACID IC50 = 790.0 nM 6.10
CHEMBL52761 — IC50 = 794.33 nM 6.10
CHEMBL100831 — IC50 = 794.33 nM 6.10
CHEMBL371456 — IC50 = 794.33 nM 6.10
CHEMBL4303669 ZOLEDRONIC ACID IC50 = 794.33 nM 6.10
CHEMBL294192 — IC50 = 820.0 nM 6.09
CHEMBL371456 — IC50 = 880.0 nM 6.06
CHEMBL374042 — IC50 = 870.0 nM 6.06
CHEMBL434024 — IC50 = 900.0 nM 6.05
CHEMBL54714 — IC50 = 910.0 nM 6.04
CHEMBL997 IBANDRONIC ACID IC50 = 920.0 nM 6.04
CHEMBL997 IBANDRONIC ACID IC50 = 1000.0 nM 6.00
CHEMBL434024 — IC50 = 1000.0 nM 6.00
CHEMBL54714 — IC50 = 1000.0 nM 6.00
CHEMBL55359 — IC50 = 1200.0 nM 5.92
CHEMBL55359 — IC50 = 1258.93 nM 5.90
CHEMBL127588 — IC50 = 2300.0 nM 5.64
CHEMBL127588 — IC50 = 2511.89 nM 5.60
CHEMBL55810 — IC50 = 3981.07 nM 5.40
CHEMBL55810 — IC50 = 4100.0 nM 5.39
CHEMBL417549 (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 5011.87 nM 5.30
CHEMBL417549 (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 5200.0 nM 5.28