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Assay Detail

CHEMBL1014434

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Functional
Growth inhibition of Plasmodium falciparum
ChEMBL ↗
52
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data.
Mukkamala D, No JH, Cass LM, Chang TK, Oldfield E.
J Med Chem (2008) 51 : 7827 -7833
PubMed 19053772 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 52 4.95 5.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55264 — — 2 5.90
CHEMBL55810 — — 2 5.70
CHEMBL56073 — — 2 5.54
CHEMBL54004 — — 2 5.50
CHEMBL196631 — — 2 5.42
CHEMBL195034 — — 2 5.40
CHEMBL198126 — — 2 5.20
CHEMBL54714 — — 2 5.00
CHEMBL56556 — — 2 5.00
CHEMBL52251 (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID — 2 4.92
CHEMBL371456 — — 2 4.70
CHEMBL127588 — — 2 4.64
CHEMBL54537 — — 2 4.64
CHEMBL294192 — — 2 4.60
CHEMBL301244 — — 2 4.50
CHEMBL997 IBANDRONIC ACID 4.0 2 4.13
CHEMBL608526 — — 2 4.05
CHEMBL417549 (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID — 2 4.00
CHEMBL100831 — — 2 -
CHEMBL923 RISEDRONIC ACID 4.0 2 -
CHEMBL52761 — — 2 -
CHEMBL55359 — — 2 -
CHEMBL4303669 ZOLEDRONIC ACID 4.0 2 -
CHEMBL374042 — — 2 -
CHEMBL267880 — — 2 -
CHEMBL434024 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55264 — IC50 = 1258.93 nM 5.90
CHEMBL55264 — IC50 = 1400.0 nM 5.85
CHEMBL55810 — IC50 = 1995.26 nM 5.70
CHEMBL55810 — IC50 = 2100.0 nM 5.68
CHEMBL56073 — IC50 = 2900.0 nM 5.54
CHEMBL56073 — IC50 = 3162.28 nM 5.50
CHEMBL54004 — IC50 = 3162.28 nM 5.50
CHEMBL54004 — IC50 = 3300.0 nM 5.48
CHEMBL196631 — IC50 = 3800.0 nM 5.42
CHEMBL196631 — IC50 = 3981.07 nM 5.40
CHEMBL195034 — IC50 = 3981.07 nM 5.40
CHEMBL195034 — IC50 = 4300.0 nM 5.37
CHEMBL198126 — IC50 = 6309.57 nM 5.20
CHEMBL198126 — IC50 = 6400.0 nM 5.19
CHEMBL56556 — IC50 = 10000.0 nM 5.00
CHEMBL54714 — IC50 = 10000.0 nM 5.00
CHEMBL56556 — IC50 = 11000.0 nM 4.96
CHEMBL54714 — IC50 = 11000.0 nM 4.96
CHEMBL52251 (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 12000.0 nM 4.92
CHEMBL52251 (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 12589.25 nM 4.90
CHEMBL371456 — IC50 = 19952.62 nM 4.70
CHEMBL371456 — IC50 = 22000.0 nM 4.66
CHEMBL54537 — IC50 = 23000.0 nM 4.64
CHEMBL127588 — IC50 = 23000.0 nM 4.64
CHEMBL127588 — IC50 = 25118.86 nM 4.60
CHEMBL54537 — IC50 = 25118.86 nM 4.60
CHEMBL294192 — IC50 = 25118.86 nM 4.60
CHEMBL294192 — IC50 = 28000.0 nM 4.55
CHEMBL301244 — IC50 = 31622.78 nM 4.50
CHEMBL301244 — IC50 = 34000.0 nM 4.47
CHEMBL997 IBANDRONIC ACID IC50 = 74000.0 nM 4.13
CHEMBL997 IBANDRONIC ACID IC50 = 79432.82 nM 4.10
CHEMBL608526 — IC50 = 90000.0 nM 4.05
CHEMBL608526 — IC50 = 100000.0 nM 4.00
CHEMBL417549 (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 100000.0 nM 4.00
CHEMBL374042 — IC50 = 180000.0 nM -
CHEMBL374042 — IC50 = 199526.23 nM -
CHEMBL4303669 ZOLEDRONIC ACID IC50 = 170000.0 nM -
CHEMBL4303669 ZOLEDRONIC ACID IC50 = 158489.32 nM -
CHEMBL55359 — IC50 = 160000.0 nM -
CHEMBL55359 — IC50 = 158489.32 nM -
CHEMBL52761 — IC50 = 130000.0 nM -
CHEMBL52761 — IC50 = 125892.54 nM -
CHEMBL923 RISEDRONIC ACID IC50 = 130000.0 nM -
CHEMBL923 RISEDRONIC ACID IC50 = 125892.54 nM -
CHEMBL100831 — IC50 = 120000.0 nM -
CHEMBL100831 — IC50 = 125892.54 nM -
CHEMBL417549 (NONYLAMINO)METHYLENEDIPHOSPHONIC ACID IC50 = 110000.0 nM -
CHEMBL434024 — IC50 = 199526.23 nM -
CHEMBL434024 — IC50 = 220000.0 nM -