Assay Detail
Binding
CHEMBL1014661
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Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.81 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513103 | — | — | 1 | 8.42 |
| CHEMBL453520 | — | — | 1 | 8.14 |
| CHEMBL460590 | — | — | 1 | 8.01 |
| CHEMBL461444 | — | — | 1 | 7.84 |
| CHEMBL509403 | — | — | 1 | 7.83 |
| CHEMBL468916 | — | — | 1 | 7.45 |
| CHEMBL502147 | — | — | 1 | 7.21 |
| CHEMBL460372 | — | — | 1 | 6.68 |
| CHEMBL508252 | — | — | 1 | 6.64 |
| CHEMBL468914 | — | — | 1 | 6.54 |
| CHEMBL450173 | — | — | 1 | 6.51 |
| CHEMBL468915 | — | — | 1 | 6.50 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 6.43 |
| CHEMBL459519 | — | — | 1 | 6.39 |
| CHEMBL459732 | — | — | 1 | 6.33 |
| CHEMBL511690 | — | — | 1 | 6.24 |
| CHEMBL336920 | (R)-DULOXETINE | — | 1 | 6.18 |
| CHEMBL512120 | — | — | 1 | 6.02 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 5.70 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513103 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL453520 | — | IC50 | = | 7.21 | nM | 8.14 |
| CHEMBL460590 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL461444 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL509403 | — | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL468916 | — | IC50 | = | 35.8 | nM | 7.45 |
| CHEMBL502147 | — | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL460372 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL508252 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL468914 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL450173 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL468915 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL1175 | DULOXETINE | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL459519 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL459732 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL511690 | — | IC50 | = | 572.0 | nM | 6.24 |
| CHEMBL336920 | (R)-DULOXETINE | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL512120 | — | IC50 | = | 957.0 | nM | 6.02 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 6000.0 | nM | 5.22 |