Assay Detail
Binding
CHEMBL1014662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometry
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.03 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 8.40 |
| CHEMBL295467 | NISOXETINE | 2.0 | 1 | 8.22 |
| CHEMBL459732 | — | — | 1 | 8.10 |
| CHEMBL468915 | — | — | 1 | 8.05 |
| CHEMBL468914 | — | — | 1 | 7.86 |
| CHEMBL336920 | (R)-DULOXETINE | — | 1 | 7.80 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 7.80 |
| CHEMBL509403 | — | — | 1 | 7.45 |
| CHEMBL450173 | — | — | 1 | 7.28 |
| CHEMBL512120 | — | — | 1 | 7.10 |
| CHEMBL453520 | — | — | 1 | 7.02 |
| CHEMBL511690 | — | — | 1 | 6.99 |
| CHEMBL459519 | — | — | 1 | 6.96 |
| CHEMBL508252 | — | — | 1 | 6.86 |
| CHEMBL461444 | — | — | 1 | 6.44 |
| CHEMBL468916 | — | — | 1 | 5.79 |
| CHEMBL460590 | — | — | 1 | 5.79 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.70 |
| CHEMBL502147 | — | — | 1 | 5.61 |
| CHEMBL513103 | — | — | 1 | 5.32 |
| CHEMBL460372 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL641 | ATOMOXETINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL295467 | NISOXETINE | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL459732 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL468915 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL468914 | — | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL336920 | (R)-DULOXETINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1175 | DULOXETINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL509403 | — | Ki | = | 35.4 | nM | 7.45 |
| CHEMBL450173 | — | Ki | = | 52.1 | nM | 7.28 |
| CHEMBL512120 | — | Ki | = | 79.7 | nM | 7.10 |
| CHEMBL453520 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL511690 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL459519 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL508252 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL461444 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL468916 | — | Ki | = | 1630.0 | nM | 5.79 |
| CHEMBL460590 | — | Ki | = | 1640.0 | nM | 5.79 |
| CHEMBL41 | FLUOXETINE | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL502147 | — | Ki | = | 2480.0 | nM | 5.61 |
| CHEMBL513103 | — | Ki | = | 4840.0 | nM | 5.32 |
| CHEMBL460372 | — | Ki | > | 10000.0 | nM | - |