Assay Detail
Binding
CHEMBL1014940
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Inhibition of Raf-1
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Virtual screening for Raf-1 kinase inhibitors based on pharmacophore model of substituted ureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.85 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350747 | — | — | 1 | 8.22 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.92 |
| CHEMBL350129 | — | — | 1 | 7.58 |
| CHEMBL514806 | — | — | 1 | 7.36 |
| CHEMBL164292 | — | — | 1 | 7.28 |
| CHEMBL165327 | — | — | 1 | 7.14 |
| CHEMBL475781 | — | — | 1 | 7.06 |
| CHEMBL512329 | — | — | 1 | 6.92 |
| CHEMBL166030 | — | — | 1 | 6.92 |
| CHEMBL448264 | — | — | 1 | 6.80 |
| CHEMBL471723 | — | — | 1 | 6.64 |
| CHEMBL166031 | — | — | 1 | 6.64 |
| CHEMBL475571 | — | — | 1 | 6.36 |
| CHEMBL514343 | — | — | 1 | 6.30 |
| CHEMBL471756 | — | — | 1 | 6.23 |
| CHEMBL470530 | — | — | 1 | 6.19 |
| CHEMBL475424 | — | — | 1 | 6.16 |
| CHEMBL472620 | — | — | 1 | 6.10 |
| CHEMBL475425 | — | — | 1 | 6.09 |
| CHEMBL475410 | — | — | 1 | 6.06 |
| CHEMBL514505 | — | — | 1 | 6.00 |
| CHEMBL471902 | — | — | 1 | 5.96 |
| CHEMBL94487 | — | — | 1 | 5.96 |
| CHEMBL511830 | — | — | 1 | 5.85 |
| CHEMBL471768 | — | — | 1 | 5.82 |
| CHEMBL279377 | — | — | 1 | 5.77 |
| CHEMBL328143 | — | — | 1 | 5.70 |
| CHEMBL475411 | — | — | 1 | 5.57 |
| CHEMBL18764 | — | — | 1 | 5.52 |
| CHEMBL18848 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350747 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL350129 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL514806 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL164292 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL165327 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL475781 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL512329 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL166030 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL448264 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL471723 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL166031 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL475571 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL514343 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL471756 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL470530 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL475424 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL472620 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL475425 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL475410 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL514505 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL471902 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL94487 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL511830 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL471768 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL279377 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL328143 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL475411 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL18764 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL18848 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL475417 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL255819 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL18852 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL96383 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL96536 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL470703 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL93264 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL96077 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL93185 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL513409 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL470529 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL92721 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL317305 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL92934 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL94156 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL95114 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL19148 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL279560 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL94581 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL318248 | — | IC50 | = | 20000.0 | nM | 4.70 |