Compound Detail
CHEMBL94487
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Basic Information
| ChEMBL ID | CHEMBL94487 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ANWRKPQVLGBTCG-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
351.4
MW (Da)
5.41
ALogP
4
HBA
2
HBD
76.4
PSA (Ų)
0.66
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase p38 CHEMBL2094115 | IC50 | 6.44 | 6.44 | 360.0 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase CHEMBL1906 | IC50 | 6.27 | 6.0375 | 540.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase p38 | IC50 | = | 360.0 | nM | 6.44 | Inhibition of Escherichia coli derived Mitogen-activated protein kinase p38 | 11591521 |
| RAF proto-oncogene serine/threonine-protein kinase | IC50 | = | 540.0 | nM | 6.27 | Inhibitory concentration against raf kinase. | 11591521 |
| RAF proto-oncogene serine/threonine-protein kinase | IC50 | = | 1100.0 | nM | 5.96 | Inhibitory activity against human Raf-1 kinase | 14741289 |
| RAF proto-oncogene serine/threonine-protein kinase | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of Raf-1 | 18947905 |
| RAF proto-oncogene serine/threonine-protein kinase | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of RAF1 (unknown origin) | 34402300 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11591521 | 10.1016/s0960-894x(01)00571-6 | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 11591521 | 10.1016/s0960-894x(01)00571-6 | MAP kinase p38 | 1 |
| 14741289 | 10.1016/j.bmcl.2003.11.041 | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 18947905 | 10.1016/j.ejmech.2008.09.016 | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 34402300 | 10.1021/acs.jmedchem.0c02167 | RAF proto-oncogene serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine