Assay Detail
Binding
CHEMBL766737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against raf kinase.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.23 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1794051 | — | — | 1 | 8.05 |
| CHEMBL94487 | — | — | 1 | 6.27 |
| CHEMBL317839 | — | — | 1 | 5.92 |
| CHEMBL279377 | — | — | 1 | 5.77 |
| CHEMBL96793 | — | — | 1 | 5.72 |
| CHEMBL328143 | — | — | 1 | 5.70 |
| CHEMBL278719 | — | — | 1 | 5.52 |
| CHEMBL18764 | — | — | 1 | 5.52 |
| CHEMBL94879 | — | — | 1 | 5.51 |
| CHEMBL317611 | — | — | 1 | 5.43 |
| CHEMBL18848 | — | — | 1 | 5.40 |
| CHEMBL18754 | — | — | 1 | 5.31 |
| CHEMBL275580 | — | — | 1 | 5.22 |
| CHEMBL96383 | — | — | 1 | 5.22 |
| CHEMBL316315 | — | — | 1 | 5.18 |
| CHEMBL96536 | — | — | 1 | 5.17 |
| CHEMBL278737 | — | — | 1 | 5.17 |
| CHEMBL93264 | — | — | 1 | 5.12 |
| CHEMBL278057 | — | — | 1 | 5.11 |
| CHEMBL96077 | — | — | 1 | 5.10 |
| CHEMBL93185 | — | — | 1 | 5.09 |
| CHEMBL92721 | — | — | 1 | 4.96 |
| CHEMBL328854 | — | — | 1 | 4.96 |
| CHEMBL328572 | — | — | 1 | 4.96 |
| CHEMBL317305 | — | — | 1 | 4.92 |
| CHEMBL317109 | — | — | 1 | 4.92 |
| CHEMBL92934 | — | — | 1 | 4.89 |
| CHEMBL94156 | — | — | 1 | 4.82 |
| CHEMBL279560 | — | — | 1 | 4.82 |
| CHEMBL96260 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1794051 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL94487 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL317839 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL279377 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL96793 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL328143 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL278719 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL18764 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL94879 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL317611 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL18848 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL18754 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL275580 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL96383 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL316315 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL96536 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL278737 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL93264 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL278057 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL96077 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL93185 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL92721 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL328854 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL328572 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL317305 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL317109 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL92934 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL279560 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL96260 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL94156 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL95114 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL19148 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL18942 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL329079 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL94581 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL318248 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL321312 | — | IC50 | = | 22000.0 | nM | 4.66 |