Assay Detail
Functional
CHEMBL1015022
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Cytotoxicity against NQ01-deficient human MDA468 cells after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.42 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511618 | — | — | 1 | 7.05 |
| CHEMBL511439 | — | — | 1 | 6.80 |
| CHEMBL469932 | — | — | 1 | 6.72 |
| CHEMBL512489 | — | — | 1 | 6.38 |
| CHEMBL517853 | — | — | 1 | 6.35 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.82 |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511618 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL511439 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL469932 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL512489 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL517853 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL383824 | ALVESPIMYCIN | IC50 | = | 1600.0 | nM | 5.80 |