Assay Detail
Binding
CHEMBL1015210
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Inhibition of heme oxygenase-1 in Sprague-Dawley rat spleen microsomal fraction assessed as carbon monoxide formation by gas chromatography
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.62 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472795 | — | — | 1 | 6.55 |
| CHEMBL421109 | — | — | 1 | 6.48 |
| CHEMBL472792 | — | — | 1 | 6.23 |
| CHEMBL474379 | — | — | 1 | 6.17 |
| CHEMBL474359 | — | — | 1 | 6.16 |
| CHEMBL463223 | — | — | 1 | 6.10 |
| CHEMBL472975 | — | — | 1 | 6.05 |
| CHEMBL473364 | — | — | 1 | 6.03 |
| CHEMBL475163 | — | — | 1 | 5.99 |
| CHEMBL464300 | — | — | 1 | 5.92 |
| CHEMBL516227 | — | — | 1 | 5.88 |
| CHEMBL473177 | — | — | 1 | 5.85 |
| CHEMBL208047 | — | — | 1 | 5.80 |
| CHEMBL459480 | — | — | 1 | 5.76 |
| CHEMBL473375 | — | — | 1 | 5.75 |
| CHEMBL472796 | — | — | 1 | 5.70 |
| CHEMBL473167 | — | — | 1 | 5.68 |
| CHEMBL515086 | — | — | 1 | 5.68 |
| CHEMBL474555 | — | — | 1 | 5.66 |
| CHEMBL474360 | — | — | 1 | 5.55 |
| CHEMBL459908 | — | — | 1 | 5.46 |
| CHEMBL516064 | — | — | 1 | 5.46 |
| CHEMBL460114 | — | — | 1 | 5.44 |
| CHEMBL179494 | — | — | 1 | 5.40 |
| CHEMBL368045 | — | — | 1 | 5.40 |
| CHEMBL472782 | — | — | 1 | 5.30 |
| CHEMBL514329 | — | — | 1 | 5.22 |
| CHEMBL514775 | — | — | 1 | 5.22 |
| CHEMBL447959 | — | — | 1 | 5.05 |
| CHEMBL474961 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472795 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL421109 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL472792 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL474379 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL474359 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL463223 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL472975 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL473364 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL475163 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL464300 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL516227 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL473177 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL208047 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL459480 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL473375 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL472796 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL515086 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL473167 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL474555 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL474360 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL459908 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL516064 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL460114 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL179494 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL368045 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL472782 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL514329 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL514775 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL447959 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL474961 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL459907 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL474572 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL460115 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3216038 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL515233 | — | IC50 | > | 100000.0 | nM | - |