Assay Detail
ADMET
CHEMBL1015213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A1/CYP3A2-catalyzed erythromycin N-demethylase activity in dexamethasone-treated Sprague-Dawley rat liver microsomes by spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.55 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208047 | — | — | 1 | 5.85 |
| CHEMBL472975 | — | — | 1 | 5.75 |
| CHEMBL475163 | — | — | 1 | 5.70 |
| CHEMBL473375 | — | — | 1 | 5.70 |
| CHEMBL515086 | — | — | 1 | 5.68 |
| CHEMBL447959 | — | — | 1 | 5.66 |
| CHEMBL473364 | — | — | 1 | 5.55 |
| CHEMBL516064 | — | — | 1 | 5.47 |
| CHEMBL464300 | — | — | 1 | 5.40 |
| CHEMBL3216038 | — | — | 1 | 5.16 |
| CHEMBL474379 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208047 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL472975 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL475163 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL473375 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL515086 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL447959 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL473364 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL516064 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL464300 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3216038 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL474379 | — | IC50 | = | 6900.0 | nM | 5.16 |