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Assay Detail

CHEMBL1015286

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Functional
Antiviral activity against HIV by pseudo-type HIV assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus (CHEMBL613758)
Type ORGANISM
Organism Human immunodeficiency virus

Publication

The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore.
Johns BA, Weatherhead JG, Allen SH, Thompson JB, Garvey EP, Foster SA, Jeffrey JL, Miller WH.
Bioorg Med Chem Lett (2009) 19 : 1802 -1806
PubMed 19217781 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 6.52 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414850 1 8.70
CHEMBL454633 1 7.89
CHEMBL199145 1 7.12
CHEMBL491150 1 6.89
CHEMBL455437 1 6.66
CHEMBL452588 1 6.62
CHEMBL522630 1 6.50
CHEMBL523974 1 6.38
CHEMBL523303 1 6.00
CHEMBL490971 1 6.00
CHEMBL510677 1 5.72
CHEMBL523302 1 5.19
CHEMBL455438 1 5.06
CHEMBL453399 1 -
CHEMBL499839 1 -
CHEMBL453400 1 -
CHEMBL491685 1 -
CHEMBL490970 1 -
CHEMBL491149 1 -
CHEMBL523468 1 -
CHEMBL490972 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414850 EC50 = 2.0 nM 8.70
CHEMBL454633 EC50 = 13.0 nM 7.89
CHEMBL199145 EC50 = 75.0 nM 7.12
CHEMBL491150 EC50 = 130.0 nM 6.89
CHEMBL455437 EC50 = 220.0 nM 6.66
CHEMBL452588 EC50 = 240.0 nM 6.62
CHEMBL522630 EC50 = 320.0 nM 6.50
CHEMBL523974 EC50 = 420.0 nM 6.38
CHEMBL523303 EC50 = 1000.0 nM 6.00
CHEMBL490971 EC50 = 1000.0 nM 6.00
CHEMBL510677 EC50 = 1900.0 nM 5.72
CHEMBL523302 EC50 = 6400.0 nM 5.19
CHEMBL455438 EC50 = 8700.0 nM 5.06
CHEMBL453399 EC50 - -
CHEMBL499839 EC50 - -
CHEMBL453400 EC50 - -
CHEMBL491685 EC50 - -
CHEMBL490970 EC50 > 35000.0 nM -
CHEMBL491149 EC50 > 20000.0 nM -
CHEMBL523468 EC50 > 35000.0 nM -
CHEMBL490972 EC50 > 35000.0 nM -