Assay Detail
Binding
CHEMBL1015290
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Binding affinity to human CB2 receptor transfected in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel tri-aryl CB2 selective cannabinoid ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.54 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119592 | — | — | 1 | 9.04 |
| CHEMBL525067 | — | — | 1 | 8.97 |
| CHEMBL460544 | — | — | 1 | 8.78 |
| CHEMBL460545 | — | — | 1 | 8.53 |
| CHEMBL460754 | — | — | 1 | 8.32 |
| CHEMBL267227 | DELTA-8-TETRAHYDROCANNABINOL | 2.0 | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119592 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL525067 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL460544 | — | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL460545 | — | Ki | = | 2.94 | nM | 8.53 |
| CHEMBL460754 | — | Ki | = | 4.77 | nM | 8.32 |
| CHEMBL267227 | DELTA-8-TETRAHYDROCANNABINOL | Ki | = | 25.0 | nM | 7.60 |