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Target Snapshot

CHEMBL253 Target Snapshot

Cannabinoid receptor 2 · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
11,244Compounds
1,495Assays
10Approved Drugs
14,043.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Cannabinoid receptor 2 shows clinical signal disease relevance led by osteoarthritis, knee. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P34972. Start with osteoarthritis, knee, then reuse UniProt P34972 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with osteoarthritis, knee, then reuse UniProt P34972 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 2 linked drugs
Open source guide
Disease program
osteoarthritis, knee

Cannabinoid receptor 2 shows clinical signal disease relevance led by osteoarthritis, knee. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with osteoarthritis, knee because it currently carries clinical signal support. Linked drugs include GW842166X, LY2828360. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cannabinoid receptor 2 as ChEMBL target CHEMBL253, mapped to UniProt P34972. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cannabinoid receptor 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL253
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P34972
Cannabinoid receptor 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cannabinoid receptor 2 is the right protein anchor across sources, using UniProt P34972 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why osteoarthritis, knee is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCannabinoid receptor 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP34972
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCannabinoid receptor 2
UniProt AccessionP34972
Component TypeProtein
Sequence Length360 aa

Cannabinoid receptor 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cannabinoid receptor 2, mapped to UniProt P34972. Sequence length is 360 aa.

Mapped IDP34972
Review nameCannabinoid receptor 2
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

Cannabinoid receptor 2 shows clinical signal disease relevance led by osteoarthritis, knee. 5 more disease programs remain visible in the same review block.

Clinical signal Phase II
osteoarthritis, knee
2 linked drugs · 2 direct · 2 efficacy
Linked drugGW842166X
Linked drugLY2828360
Clinical signal Phase II
Abdominal pain
1 linked drug · 1 direct · 1 efficacy
Linked drugOLORINAB
Clinical signal Phase II
atopic eczema
1 linked drug · 1 direct · 1 efficacy
Linked drugS-777469
Clinical signal Phase II
Crohn's disease
1 linked drug · 1 direct · 1 efficacy
Linked drugOLORINAB
Clinical signal Phase II
irritable bowel syndrome
1 linked drug · 1 direct · 1 efficacy
Linked drugOLORINAB
Clinical signal Phase II
osteoarthritis
1 linked drug · 1 direct · 1 efficacy
Linked drugGW842166X
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with osteoarthritis, knee because it currently carries clinical signal support. Linked drugs include GW842166X, LY2828360. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseosteoarthritis, knee
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

10
Approved
9
Phase III
22
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC502,053.0
KI6,528.0
EC505,448.0
KD14.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1822945 11.0 Ki 0.01 Preclinical
CHEMBL1822939 10.85 Ki 0.014 Preclinical
CHEMBL499066 10.82 EC50 0.015 Preclinical
CHEMBL600647 10.72 Ki 0.019 Preclinical
CHEMBL1822944 10.7 Ki 0.02 Preclinical
CHEMBL1822940 10.68 Ki 0.021 Preclinical
CHEMBL3410832 10.68 Ki 0.02099 Preclinical
CHEMBL371214 10.64 Ki 0.023 Preclinical
CHEMBL3410813 10.59 Ki 0.026 Preclinical
CHEMBL1277685 10.49 Ki 0.032 Preclinical
Distribution

pChEMBL Value Distribution

722
5.0
978
5.5
1447
6.0
1477
6.5
1677
7.0
1560
7.5
1328
8.0
819
8.5
479
9.0
121
9.5
pChEMBL
Approved Drugs

Approved Drugs

CANNABIDIOL
CHEMBL190461
Approved 2018
Properties Compare Identifier
RIMONABANT
CHEMBL111
Approved 2006
Properties Compare Identifier
NABILONE
CHEMBL2218896
Approved 1985
Properties Compare Identifier
DRONABINOL
CHEMBL465
Approved 1985
Properties Compare Identifier
Assay Landscape

Assay Landscape

1,495
Total Assays
5,873
Tested Compounds
3
Assay Types
Binding — 813 assays, 5,873 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 443 3,190 6.9
single protein format 279 1,443 7.3
cell membrane format 45 183 7.0
assay format 44 1,028 7.5
cell-free format 1 24 6.7
tissue-based format 1 5 8.0
Functional — 677 assays, 3,158 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 552 2,638 7.3
assay format 77 381 7.4
cell membrane format 43 60 7.2
single protein format 5 79 6.2
ADME — 5 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell membrane format 3 0 —
cell-based format 1 13 5.8
single protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine