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Compound Detail

CHEMBL499066

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Fc1ccc(-c2noc(CCCNc3ccc4ncc(OC(F)(F)F)cc4c3)n2)c(Cl)c1

Basic Information

ChEMBL ID CHEMBL499066
Phase Preclinical
Structure Type MOL
InChI Key HBTYATWGNXKNSB-UHFFFAOYSA-N
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

466.8
MW (Da)
6.02
ALogP
6
HBA
1
HBD
73.1
PSA (Ų)
0.27
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H15ClF4N4O2
MW 466.82
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -2.15

Activity Summary

EC50 6 meas. best 10.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 2
CHEMBL253
EC50 10.82 9.73 0.0 2
Cannabinoid receptor 2
CHEMBL2470
EC50 8.89 8.89 1.3 1
Cannabinoid receptor 1
CHEMBL3571
EC50 6.89 6.89 130.0 1
Cannabinoid receptor 1
CHEMBL218
EC50 6.07 6.015 850.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18680277 10.1021/jm800463f Cannabinoid receptor 1 6
18680277 10.1021/jm800463f Cannabinoid receptor 2 6
18680277 10.1021/jm800463f No relevant target 1

Data from ChEMBL 36 via Core Engine