Assay Detail
Functional
CHEMBL1006424
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Agonist activity at rat recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP level
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of a novel series of N-arylamide oxadiazoles as potent, highly selective and orally bioavailable cannabinoid receptor 2 (CB2) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 6.79 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 9.80 |
| CHEMBL499065 | — | — | 1 | 7.11 |
| CHEMBL498469 | — | — | 1 | 7.08 |
| CHEMBL499066 | — | — | 1 | 6.89 |
| CHEMBL526345 | — | — | 1 | 6.89 |
| CHEMBL500655 | — | — | 1 | 6.82 |
| CHEMBL499060 | — | — | 1 | 6.77 |
| CHEMBL502263 | — | — | 1 | 6.66 |
| CHEMBL499050 | — | — | 1 | 6.66 |
| CHEMBL525019 | — | — | 1 | 6.62 |
| CHEMBL499324 | — | — | 1 | 6.62 |
| CHEMBL501472 | — | — | 1 | 6.55 |
| CHEMBL527095 | — | — | 1 | 6.48 |
| CHEMBL524826 | — | — | 1 | 6.27 |
| CHEMBL499059 | — | — | 1 | 6.24 |
| CHEMBL499628 | — | — | 1 | 6.19 |
| CHEMBL498470 | — | — | 1 | 5.80 |
| CHEMBL499877 | — | — | 1 | - |
| CHEMBL499626 | — | — | 1 | - |
| CHEMBL499332 | — | — | 1 | - |
| CHEMBL526322 | — | — | 1 | - |
| CHEMBL453993 | — | — | 1 | - |
| CHEMBL499331 | — | — | 1 | - |
| CHEMBL498324 | — | — | 1 | - |
| CHEMBL499627 | — | — | 1 | - |
| CHEMBL498323 | — | — | 1 | - |
| CHEMBL498322 | — | — | 1 | - |
| CHEMBL540704 | — | — | 1 | - |
| CHEMBL527051 | — | — | 1 | - |
| CHEMBL499601 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL499065 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL498469 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL499066 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL526345 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL500655 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL499060 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL502263 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL499050 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL525019 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL499324 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL501472 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL527095 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL524826 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL499059 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL499628 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL498470 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL526471 | — | EC50 | - | — | - | |
| CHEMBL498795 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL500670 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL524839 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL500927 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL500926 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL524680 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL500134 | — | EC50 | - | — | - | |
| CHEMBL500133 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL499874 | — | EC50 | - | — | - | |
| CHEMBL499328 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL499601 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL527051 | — | EC50 | - | — | - | |
| CHEMBL540704 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL498322 | — | EC50 | - | — | - | |
| CHEMBL498323 | — | EC50 | - | — | - | |
| CHEMBL499627 | — | EC50 | - | — | - | |
| CHEMBL498324 | — | EC50 | - | — | - | |
| CHEMBL499331 | — | EC50 | - | — | - | |
| CHEMBL453993 | — | EC50 | - | — | - | |
| CHEMBL526322 | — | EC50 | - | — | - | |
| CHEMBL499332 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL499626 | — | EC50 | - | — | - | |
| CHEMBL499877 | — | EC50 | - | — | - |