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Compound Detail

CHEMBL524826

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CC(C)(C)c1ncc(OCCCc2nc(-c3ccc(F)cc3Cl)no2)cn1

Basic Information

ChEMBL ID CHEMBL524826
Phase Preclinical
Structure Type MOL
InChI Key GASFAQIEJVLYMT-UHFFFAOYSA-N
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

390.9
MW (Da)
4.63
ALogP
6
HBA
0
HBD
73.9
PSA (Ų)
0.57
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H20ClFN4O2
MW 390.85
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -2.08

Activity Summary

EC50 6 meas. best 8.31

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 2
CHEMBL253
EC50 8.31 7.965 4.9 2
Cannabinoid receptor 2
CHEMBL2470
EC50 7.8 7.8 16.0 1
Cannabinoid receptor 1
CHEMBL3571
EC50 6.27 6.27 540.0 1
Cannabinoid receptor 1
CHEMBL218
EC50 6.21 6.015 610.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18680277 10.1021/jm800463f Cannabinoid receptor 1 6
18680277 10.1021/jm800463f Cannabinoid receptor 2 6

Data from ChEMBL 36 via Core Engine