Assay Detail
Functional
CHEMBL1015294
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MrgX2 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mas-related G-protein coupled receptor member X2 (CHEMBL5849) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of non-peptidergic MrgX1 and MrgX2 receptor agonists and exploration of an initial SAR using solid-phase synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.26 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503688 | — | — | 1 | 6.80 |
| CHEMBL463274 | — | — | 1 | 6.50 |
| CHEMBL502480 | — | — | 1 | 6.40 |
| CHEMBL2448526 | CORTISTATIN-14 | — | 1 | 6.30 |
| CHEMBL502132 | — | — | 1 | 6.20 |
| CHEMBL503202 | — | — | 1 | 5.90 |
| CHEMBL505263 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503688 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL463274 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL502480 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL2448526 | CORTISTATIN-14 | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL502132 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL503202 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL505263 | — | EC50 | = | 1995.26 | nM | 5.70 |