Assay Detail

CHEMBL1015350

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Functional

Inhibition of prostaglandin F2alpha-induced contraction in human lung bronchus

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Tissue	Bronchus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.

Procopiou PA, Barrett VJ, Bevan NJ, Biggadike K, Butchers PR, Coe DM, Conroy R, Edney DD, Field RN, Ford AJ, Guntrip SB, Looker BE, McLay IM, Monteith MJ, Morrison VS, Mutch PJ, Richards SA, Sasse R, Smith CE.
J Med Chem (2009) 52 : 2280 -2288
PubMed 19317397 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	8.46	8.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL446840	—	—	1	8.62
CHEMBL1263	SALMETEROL	4.0	1	8.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL446840	—	EC50	=	2.4	nM	8.62
CHEMBL1263	SALMETEROL	EC50	=	5.0	nM	8.30