Assay Detail
Functional
CHEMBL1015476
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H69 cells after 72 hrs by trypan blue exclusion assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Non-peptide macrocyclic histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.51 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455735 | — | — | 1 | 5.84 |
| CHEMBL472250 | — | — | 1 | 5.83 |
| CHEMBL490446 | — | — | 1 | 5.75 |
| CHEMBL446811 | — | — | 1 | 5.72 |
| CHEMBL501640 | — | — | 1 | 5.72 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.69 |
| CHEMBL498908 | — | — | 1 | 5.57 |
| CHEMBL504040 | — | — | 1 | 5.52 |
| CHEMBL506834 | — | — | 1 | 5.46 |
| CHEMBL507617 | — | — | 1 | 5.40 |
| CHEMBL455342 | — | — | 1 | 5.34 |
| CHEMBL503113 | — | — | 1 | 5.29 |
| CHEMBL502430 | — | — | 1 | 5.25 |
| CHEMBL499994 | — | — | 1 | 5.14 |
| CHEMBL509089 | — | — | 1 | 5.07 |
| CHEMBL510806 | AZITHROMYCINARYLALKYLHYDROXAMIC ACID | — | 1 | - |
| CHEMBL454025 | DESCLASINOSE AZITHROMYCINARYLALKYL HYDROXAMATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455735 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL472250 | — | EC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL490446 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL446811 | — | EC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL501640 | — | EC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL498908 | — | EC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL504040 | — | EC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL506834 | — | EC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL507617 | — | EC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL455342 | — | EC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL503113 | — | EC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL502430 | — | EC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL499994 | — | EC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL509089 | — | EC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL510806 | AZITHROMYCINARYLALKYLHYDROXAMIC ACID | EC50 | - | — | - | |
| CHEMBL454025 | DESCLASINOSE AZITHROMYCINARYLALKYL HYDROXAMATE | EC50 | - | — | - |