Assay Detail
Binding
CHEMBL1015636
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Inhibition of ACE by fluorometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Chemical and pharmaceutical studies on medicinal plants in Paraguay. Geraniin, an angiotensin-converting enzyme inhibitor from "paraparai mi," Phyllanthus niruri.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 8.30 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | - |
| CHEMBL449392 | CORILAGIN | — | 1 | - |
| CHEMBL288114 | GALLIC ACID | 2.0 | 1 | - |
| CHEMBL506069 | GERANIIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 5000000.0 | nM | - |
| CHEMBL449392 | CORILAGIN | IC50 | = | 3700000.0 | nM | - |
| CHEMBL288114 | GALLIC ACID | IC50 | = | 7700000.0 | nM | - |
| CHEMBL506069 | GERANIIN | IC50 | = | 400000.0 | nM | - |