Assay Detail
Functional
CHEMBL1015914
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Cytotoxicity against human NCI/ADR cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.04 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364447 | DISERMOLIDE | 2.0 | 1 | 7.77 |
| CHEMBL505063 | — | — | 1 | 5.55 |
| CHEMBL448959 | — | — | 1 | 5.47 |
| CHEMBL455291 | — | — | 1 | 5.36 |
| CHEMBL449683 | — | — | 1 | - |
| CHEMBL499911 | — | — | 1 | - |
| CHEMBL442688 | — | — | 1 | - |
| CHEMBL450557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364447 | DISERMOLIDE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL505063 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL448959 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL455291 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL449683 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL499911 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL442688 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL450557 | — | IC50 | > | 5000.0 | nM | - |