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Assay Detail

CHEMBL1015997

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant HDAC4 by fluorimetric assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Histone deacetylase 4 (CHEMBL3524)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.
Wang H, Yu N, Song H, Chen D, Zou Y, Deng W, Lye PL, Chang J, Ng M, Sun ET, Sangthongpitag K, Wang X, Wu X, Khng HH, Fang L, Goh SK, Ong WC, Bonday Z, Stünkel W, Poulsen A, Entzeroth M.
Bioorg Med Chem Lett (2009) 19 : 1403 -1408
PubMed 19181524 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.02 8.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL491316 1 8.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL491316 Ki = 9.6 nM 8.02