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Assay Detail

CHEMBL1016111

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Functional
Cytotoxicity against human Molt4/C8 cells after 72 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MOLT-4
Confidence 1 — Organism
Curated By Autocuration

Publication

The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones.
Pati HN, Das U, Das S, Bandy B, De Clercq E, Balzarini J, Kawase M, Sakagami H, Quail JW, Stables JP, Dimmock JR.
Eur J Med Chem (2009) 44 : 54 -62
PubMed 18468733 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.26 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL515242 1 5.70
CHEMBL472965 1 5.62
CHEMBL852 MELPHALAN 4.0 1 5.49
CHEMBL516349 1 5.07
CHEMBL99296 1 4.43
CHEMBL473575 1 -
CHEMBL473574 1 -
CHEMBL473013 1 -
CHEMBL473014 1 -
CHEMBL514971 1 -
CHEMBL474956 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL515242 IC50 = 1980.0 nM 5.70
CHEMBL472965 IC50 = 2420.0 nM 5.62
CHEMBL852 MELPHALAN IC50 = 3240.0 nM 5.49
CHEMBL516349 IC50 = 8510.0 nM 5.07
CHEMBL99296 IC50 = 36900.0 nM 4.43
CHEMBL473575 IC50 = 230000.0 nM -
CHEMBL473574 IC50 = 277000.0 nM -
CHEMBL473013 IC50 > 500000.0 nM -
CHEMBL473014 IC50 > 500000.0 nM -
CHEMBL514971 IC50 > 500000.0 nM -
CHEMBL474956 IC50 > 500000.0 nM -