Assay Detail
Functional
CHEMBL1016165
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Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 7.52 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474387 | — | — | 1 | 8.70 |
| CHEMBL522491 | — | — | 1 | 8.70 |
| CHEMBL444724 | — | — | 1 | 8.70 |
| CHEMBL516047 | — | — | 1 | 8.52 |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 8.52 |
| CHEMBL515260 | — | — | 1 | 8.40 |
| CHEMBL474388 | — | — | 1 | 8.40 |
| CHEMBL492725 | — | — | 1 | 8.40 |
| CHEMBL444972 | — | — | 1 | 8.40 |
| CHEMBL522156 | — | — | 1 | 8.05 |
| CHEMBL493725 | — | — | 1 | 8.05 |
| CHEMBL450582 | — | — | 1 | 7.96 |
| CHEMBL474386 | — | — | 1 | 7.92 |
| CHEMBL492723 | — | — | 1 | 7.89 |
| CHEMBL475565 | — | — | 1 | 7.85 |
| CHEMBL506330 | — | — | 1 | 7.82 |
| CHEMBL475846 | — | — | 1 | 7.72 |
| CHEMBL473998 | — | — | 1 | 7.58 |
| CHEMBL483576 | — | — | 1 | 7.48 |
| CHEMBL450198 | — | — | 1 | 7.44 |
| CHEMBL493724 | — | — | 1 | 7.37 |
| CHEMBL483615 | — | — | 1 | 7.36 |
| CHEMBL492724 | — | — | 1 | 7.32 |
| CHEMBL453919 | — | — | 1 | 7.12 |
| CHEMBL503751 | — | — | 1 | 7.08 |
| CHEMBL475221 | — | — | 1 | 6.89 |
| CHEMBL483616 | — | — | 1 | 6.82 |
| CHEMBL475381 | — | — | 1 | 6.60 |
| CHEMBL492325 | — | — | 1 | 6.34 |
| CHEMBL475658 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474387 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL444724 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL522491 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL516047 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL492399 | VERUBULIN | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL515260 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL474388 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL492725 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL444972 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL522156 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL493725 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL450582 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL474386 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL492723 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL475565 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL506330 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL475846 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL473998 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL483576 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL450198 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL493724 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL483615 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL492724 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL453919 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL503751 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL475221 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL483616 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL475381 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL492325 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL475658 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL442844 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL494943 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL495141 | — | EC50 | = | 6100.0 | nM | 5.21 |