Assay Detail
Functional
CHEMBL1016166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-398 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 33 | 7.67 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522491 | — | — | 1 | 9.00 |
| CHEMBL444724 | — | — | 1 | 8.70 |
| CHEMBL474387 | — | — | 1 | 8.70 |
| CHEMBL492725 | — | — | 1 | 8.70 |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 8.70 |
| CHEMBL444972 | — | — | 1 | 8.52 |
| CHEMBL516047 | — | — | 1 | 8.52 |
| CHEMBL515260 | — | — | 1 | 8.40 |
| CHEMBL474388 | — | — | 1 | 8.40 |
| CHEMBL493725 | — | — | 1 | 8.30 |
| CHEMBL492723 | — | — | 1 | 8.10 |
| CHEMBL522156 | — | — | 1 | 8.00 |
| CHEMBL506330 | — | — | 1 | 8.00 |
| CHEMBL450582 | — | — | 1 | 8.00 |
| CHEMBL474386 | — | — | 1 | 7.96 |
| CHEMBL475565 | — | — | 1 | 7.89 |
| CHEMBL483615 | — | — | 1 | 7.75 |
| CHEMBL475846 | — | — | 1 | 7.72 |
| CHEMBL483576 | — | — | 1 | 7.70 |
| CHEMBL450198 | — | — | 1 | 7.70 |
| CHEMBL473998 | — | — | 1 | 7.68 |
| CHEMBL493724 | — | — | 1 | 7.48 |
| CHEMBL453919 | — | — | 1 | 7.31 |
| CHEMBL503751 | — | — | 1 | 7.18 |
| CHEMBL475221 | — | — | 1 | 7.06 |
| CHEMBL483616 | — | — | 1 | 6.89 |
| CHEMBL475381 | — | — | 1 | 6.77 |
| CHEMBL492325 | — | — | 1 | 6.57 |
| CHEMBL475658 | — | — | 1 | 6.41 |
| CHEMBL442844 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522491 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL444724 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL492399 | VERUBULIN | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL492725 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL474387 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL444972 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL516047 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL515260 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL474388 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL493725 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL492723 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL522156 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL506330 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL450582 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL474386 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL475565 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL483615 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL475846 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL483576 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL450198 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL473998 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL493724 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL453919 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL503751 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL475221 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL483616 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL475381 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL492325 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL475658 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL442844 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL494943 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL495141 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL492724 | — | EC50 | - | — | - |