Assay Detail
Binding
CHEMBL1016193
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Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Cell Type | S2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.49 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.22 |
| CHEMBL430060 | APICIDIN | — | 1 | 9.00 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.74 |
| CHEMBL490032 | — | — | 1 | 7.82 |
| CHEMBL519035 | — | — | 1 | 7.70 |
| CHEMBL490229 | — | — | 1 | 7.66 |
| CHEMBL307765 | — | — | 1 | 7.44 |
| CHEMBL491254 | — | — | 1 | 7.43 |
| CHEMBL490230 | — | — | 1 | 7.43 |
| CHEMBL447806 | — | — | 1 | 7.39 |
| CHEMBL490228 | — | — | 1 | 7.37 |
| CHEMBL446605 | — | — | 1 | 7.35 |
| CHEMBL491253 | — | — | 1 | 7.31 |
| CHEMBL508866 | — | — | 1 | 7.23 |
| CHEMBL523640 | — | — | 1 | 7.23 |
| CHEMBL489011 | — | — | 1 | 7.23 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.23 |
| CHEMBL491452 | — | — | 1 | 7.05 |
| CHEMBL489218 | — | — | 1 | 7.05 |
| CHEMBL489010 | — | — | 1 | 6.97 |
| CHEMBL485506 | — | — | 1 | 6.96 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.03 |
| CHEMBL86537 | SPLITOMICIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL430060 | APICIDIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL490032 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL519035 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL490229 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL307765 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL491254 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL490230 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL447806 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL490228 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL446605 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL491253 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL508866 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL523640 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL489011 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL491452 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL489218 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL489010 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL485506 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL86537 | SPLITOMICIN | IC50 | > | 10000.0 | nM | - |