Assay Detail
Functional
CHEMBL1016199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human CCRF-CEM cells after 72 hrs by alamar-blue cell viability assay
12
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.66 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514671 | — | — | 1 | 6.15 |
| CHEMBL514351 | — | — | 2 | 6.14 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.10 |
| CHEMBL1080580 | — | — | 1 | 5.89 |
| CHEMBL473825 | — | — | 1 | 5.85 |
| CHEMBL474863 | — | — | 1 | 5.75 |
| CHEMBL475820 | — | — | 1 | 5.70 |
| CHEMBL475796 | — | — | 2 | 5.70 |
| CHEMBL941 | IMATINIB | 4.0 | 2 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514671 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL514351 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL514351 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL1080580 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL473825 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL474863 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL475820 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL475796 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL475796 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL941 | IMATINIB | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL941 | IMATINIB | IC50 | = | 39810.72 | nM | 4.40 |