Assay Detail
Functional
CHEMBL1016202
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Cytotoxicity against human HCT116 cells after 3 days by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.20 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477259 | — | — | 1 | 6.82 |
| CHEMBL514678 | — | — | 1 | 6.82 |
| CHEMBL451298 | — | — | 1 | 6.60 |
| CHEMBL477877 | — | — | 1 | 6.42 |
| CHEMBL478488 | — | — | 1 | 6.38 |
| CHEMBL515631 | — | — | 1 | 6.37 |
| CHEMBL452447 | — | — | 1 | 6.36 |
| CHEMBL489629 | — | — | 1 | 6.32 |
| CHEMBL504547 | — | — | 1 | 6.32 |
| CHEMBL521922 | — | — | 1 | 6.26 |
| CHEMBL477861 | — | — | 1 | 6.19 |
| CHEMBL477863 | — | — | 1 | 6.17 |
| CHEMBL477064 | — | — | 1 | 6.14 |
| CHEMBL490240 | — | — | 1 | 6.09 |
| CHEMBL477063 | — | — | 1 | 5.89 |
| CHEMBL489245 | — | — | 1 | 5.70 |
| CHEMBL477860 | — | — | 1 | 5.64 |
| CHEMBL478487 | — | — | 1 | 5.17 |
| CHEMBL477862 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477259 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL514678 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL451298 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL477877 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL478488 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL515631 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL452447 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL489629 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL504547 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL521922 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL477861 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL477863 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL477064 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL490240 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL477063 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL489245 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL477860 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL478487 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL477862 | — | IC50 | > | 50000.0 | nM | - |