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Assay Detail

CHEMBL1016857

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at Agrobacterium tumefaciens WCF47 TraR receptor assessed as inhibition of OOHL-induced response by beta-galctosidase reporter gene assay
42
Total Activities
41
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Agrobacterium tumefaciens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Transcriptional activator protein TraR (CHEMBL5865)
Type SINGLE PROTEIN
Organism Agrobacterium tumefaciens

Publication

Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators.
Geske GD, Mattmann ME, Blackwell HE.
Bioorg Med Chem Lett (2008) 18 : 5978 -5981
PubMed 18760602 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 5.86 6.68
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL467396 1 6.68
CHEMBL501141 1 6.54
CHEMBL502443 1 6.36
CHEMBL503197 1 6.34
CHEMBL512914 1 6.29
CHEMBL503754 1 6.21
CHEMBL468624 1 6.09
CHEMBL264944 1 6.04
CHEMBL456059 1 5.96
CHEMBL442902 1 5.96
CHEMBL468790 1 5.90
CHEMBL458671 1 5.80
CHEMBL503238 1 5.80
CHEMBL456058 2 5.75
CHEMBL467397 1 5.68
CHEMBL468791 1 5.65
CHEMBL509975 1 5.62
CHEMBL498921 1 5.57
CHEMBL457113 1 5.48
CHEMBL502197 1 5.38
CHEMBL508554 1 5.37
CHEMBL458227 1 5.33
CHEMBL456052 1 5.08
CHEMBL499747 1 -
CHEMBL450689 1 -
CHEMBL513503 1 -
CHEMBL463121 1 -
CHEMBL457115 1 -
CHEMBL444924 1 -
CHEMBL456928 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL467396 IC50 = 210.0 nM 6.68
CHEMBL501141 IC50 = 290.0 nM 6.54
CHEMBL502443 IC50 = 440.0 nM 6.36
CHEMBL503197 IC50 = 460.0 nM 6.34
CHEMBL512914 IC50 = 510.0 nM 6.29
CHEMBL503754 IC50 = 620.0 nM 6.21
CHEMBL468624 IC50 = 810.0 nM 6.09
CHEMBL264944 IC50 = 920.0 nM 6.04
CHEMBL456059 IC50 = 1100.0 nM 5.96
CHEMBL442902 IC50 = 1100.0 nM 5.96
CHEMBL468790 IC50 = 1250.0 nM 5.90
CHEMBL503238 IC50 = 1600.0 nM 5.80
CHEMBL458671 IC50 = 1600.0 nM 5.80
CHEMBL456058 IC50 = 1800.0 nM 5.75
CHEMBL467397 IC50 = 2100.0 nM 5.68
CHEMBL468791 IC50 = 2250.0 nM 5.65
CHEMBL509975 IC50 = 2400.0 nM 5.62
CHEMBL498921 IC50 = 2700.0 nM 5.57
CHEMBL457113 IC50 = 3300.0 nM 5.48
CHEMBL502197 IC50 = 4200.0 nM 5.38
CHEMBL508554 IC50 = 4300.0 nM 5.37
CHEMBL458227 IC50 = 4700.0 nM 5.33
CHEMBL456052 IC50 = 8400.0 nM 5.08
CHEMBL458672 IC50 - -
CHEMBL258912 IC50 - -
CHEMBL405298 IC50 - -
CHEMBL457057 IC50 - -
CHEMBL459083 IC50 - -
CHEMBL459084 IC50 - -
CHEMBL458226 IC50 - -
CHEMBL511677 IC50 - -
CHEMBL508553 IC50 - -
CHEMBL456058 Inhibition = 84.0 % -
CHEMBL456719 IC50 - -
CHEMBL506438 IC50 - -
CHEMBL456928 IC50 - -
CHEMBL444924 IC50 - -
CHEMBL463121 IC50 - -
CHEMBL513503 IC50 - -
CHEMBL450689 IC50 - -
CHEMBL499747 IC50 - -
CHEMBL457115 IC50 - -