Assay Detail
Functional
CHEMBL1016908
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.51 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23013 | PROPAMIDINE | 3.0 | 1 | 8.25 |
| CHEMBL142304 | STILBAMIDINE | 2.0 | 1 | 7.57 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23013 | PROPAMIDINE | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL142304 | STILBAMIDINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL35241 | DIMINAZENE | IC50 | = | 190.0 | nM | 6.72 |