Compound Detail
CHEMBL35241
DIMINAZENE 🧪 Phase II
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL35241 |
| Name | DIMINAZENE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | XNYZHCFCZNMTFY-UHFFFAOYSA-N |
17
Targets
76
Activities
4
Assay Types
0
PK Parameters
20
Publications
4
Known Names
Molecular Properties
281.3
MW (Da)
2.37
ALogP
4
HBA
5
HBD
136.5
PSA (Ų)
0.25
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
EC50 50 meas. best 8.0
IC50 19 meas. best 8.52
Ki 4 meas. best 7.89
Kd 3 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Kd | 9.0 | 7.49 | 1.0 | 3 |
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 8.52 | 7.3063 | 3.0 | 8 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 8.24 | 8.24 | 5.8 | 1 |
| Trypanosoma brucei CHEMBL612849 | EC50 | 8.0 | 6.205 | 10.0 | 12 |
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 7.92 | 6.5677 | 12.0 | 22 |
| Diamine oxidase [copper-containing] CHEMBL2118 | Ki | 7.89 | 7.89 | 13.0 | 1 |
| Trypanosoma evansi CHEMBL1075362 | EC50 | 7.75 | 7.75 | 18.0 | 1 |
| Trypanosoma brucei CHEMBL612849 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| Trypanosoma congolense CHEMBL4296607 | EC50 | 7.52 | 6.5586 | 30.0 | 7 |
| Trypanosoma vivax CHEMBL5209658 | EC50 | 6.77 | 6.77 | 170.0 | 1 |
| Plasmodium falciparum CHEMBL364 | IC50 | 6.72 | 6.72 | 190.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Furin CHEMBL2611 | IC50 | 6.24 | 6.24 | 580.0 | 1 |
| Transmembrane protease serine 2 CHEMBL1795140 | IC50 | 5.87 | 5.87 | 1350.0 | 1 |
| Diamine acetyltransferase 1 CHEMBL4286 | Ki | 5.62 | 5.62 | 2400.0 | 1 |
| L6 CHEMBL614793 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
| Furin CHEMBL2611 | Ki | 5.27 | 5.27 | 5420.0 | 1 |
| Angiotensin-converting enzyme 2 CHEMBL3736 | EC50 | 5.09 | 5.09 | 8040.0 | 1 |
| L1210 CHEMBL386 | IC50 | 4.5 | 4.5 | 32000.0 | 1 |
| Acid-sensing ion channel 1/2 CHEMBL4523651 | IC50 | 4.34 | 4.34 | 45200.0 | 1 |
| Acid-sensing ion channel 1 CHEMBL3232694 | IC50 | 4.25 | 4.25 | 56900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine