Assay Detail
Functional
CHEMBL1648845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 after 70 hrs by alamar blue assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.99 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.89 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 8.24 |
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.00 |
| CHEMBL1644656 | — | — | 1 | 7.96 |
| CHEMBL566743 | — | — | 1 | 7.92 |
| CHEMBL1644658 | — | — | 1 | 7.89 |
| CHEMBL1644660 | — | — | 1 | 7.85 |
| CHEMBL1644655 | — | — | 1 | 7.60 |
| CHEMBL1644664 | — | — | 1 | 7.38 |
| CHEMBL1644659 | — | — | 1 | 7.29 |
| CHEMBL1644661 | — | — | 1 | 7.14 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 6.92 |
| CHEMBL1644657 | — | — | 1 | 6.55 |
| CHEMBL1644667 | — | — | 1 | 5.35 |
| CHEMBL1644665 | — | — | 1 | 5.05 |
| CHEMBL1644653 | — | — | 1 | 4.39 |
| CHEMBL1644662 | — | — | 1 | 4.37 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
| CHEMBL1644666 | — | — | 1 | - |
| CHEMBL1644663 | — | — | 1 | - |
| CHEMBL1644654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL35241 | DIMINAZENE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL166 | MELARSOPROL | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL1644656 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL566743 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1644658 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1644660 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1644655 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1644664 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1644659 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1644661 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL265502 | SURAMIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1644657 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1644667 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1644665 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1644653 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1644662 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL61 | PODOFILOX | IC50 | - | — | - | |
| CHEMBL1644666 | — | IC50 | - | — | - | |
| CHEMBL1644663 | — | IC50 | - | — | - | |
| CHEMBL1644654 | — | IC50 | = | 140000.0 | nM | - |