Assay Detail
Functional
CHEMBL3804505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms incubated for 48 hrs by alamar blue assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.46 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 8.30 |
| CHEMBL3799766 | — | — | 1 | 8.27 |
| CHEMBL338227 | — | — | 1 | 8.17 |
| CHEMBL3797456 | — | — | 1 | 8.14 |
| CHEMBL3798543 | — | — | 1 | 7.72 |
| CHEMBL395187 | — | — | 1 | 7.40 |
| CHEMBL3797687 | — | — | 1 | 6.77 |
| CHEMBL394377 | — | — | 1 | 6.75 |
| CHEMBL396361 | — | — | 1 | 6.75 |
| CHEMBL3798852 | — | — | 1 | 6.68 |
| CHEMBL3798718 | — | — | 1 | 6.66 |
| CHEMBL126486 | — | — | 1 | 6.55 |
| CHEMBL237235 | — | — | 1 | 6.52 |
| CHEMBL394275 | — | — | 1 | 6.42 |
| CHEMBL391515 | — | — | 1 | 6.41 |
| CHEMBL3798709 | — | — | 1 | 6.40 |
| CHEMBL236563 | — | — | 1 | 6.21 |
| CHEMBL236564 | — | — | 1 | 6.20 |
| CHEMBL3800015 | — | — | 1 | 6.15 |
| CHEMBL3798376 | — | — | 1 | 6.14 |
| CHEMBL95965 | — | — | 1 | 6.10 |
| CHEMBL3798328 | — | — | 1 | 6.10 |
| CHEMBL3797620 | — | — | 1 | 6.01 |
| CHEMBL3797790 | — | — | 1 | 5.66 |
| CHEMBL3800142 | — | — | 1 | 5.40 |
| CHEMBL3800571 | — | — | 1 | 5.31 |
| CHEMBL235083 | — | — | 1 | 5.30 |
| CHEMBL3797682 | — | — | 1 | 4.57 |
| CHEMBL3798993 | — | — | 1 | 4.32 |
| CHEMBL397524 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35241 | DIMINAZENE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3799766 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL338227 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3797456 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3798543 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL395187 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3797687 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL394377 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL396361 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3798852 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3798718 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL126486 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL237235 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL394275 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL391515 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3798709 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL236563 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL236564 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3800015 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3798376 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL95965 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3798328 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3797620 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL3797790 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3800142 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3800571 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL235083 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3797682 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3798993 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL397524 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL236153 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL235938 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL235026 | — | IC50 | > | 75000.0 | nM | - |