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Target Snapshot

CHEMBL4286 Target Snapshot

Diamine acetyltransferase 1 · SINGLE PROTEIN · Homo sapiens

37Compounds
22Assays
1Approved Drugs
5.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P21673. Use UniProt P21673 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P21673 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Diamine acetyltransferase 1 as ChEMBL target CHEMBL4286, mapped to UniProt P21673. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Diamine acetyltransferase 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4286
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P21673
Diamine acetyltransferase 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Diamine acetyltransferase 1 is the right protein anchor across sources, using UniProt P21673 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDiamine acetyltransferase 1
UniProt AccessionP21673
Component TypeProtein
Sequence Length171 aa

Diamine acetyltransferase 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Diamine acetyltransferase 1, mapped to UniProt P21673. Sequence length is 171 aa.

Mapped IDP21673
Review nameDiamine acetyltransferase 1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC502.0
KI3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL55 5.7 Ki 2000.0 Approved
CHEMBL35241 5.62 Ki 2400.0 Clinical
CHEMBL86940 4.4 IC50 40000.0 Preclinical
CHEMBL315330 4.3 Ki 50000.0 Preclinical
CHEMBL33387 4.0 IC50 100000.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
2
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

22
Total Assays
5
Tested Compounds
2
Assay Types
ADME — 12 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 0
single protein format 2 0
Binding — 10 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 2 4.2
single protein format 2 3 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine