Assay Detail
Functional
CHEMBL1099530
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Antitrypanosomal activity against Trypanosoma evansi ITMAV170475 after 48 hrs by alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma evansi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.09 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 7.75 |
| CHEMBL1086746 | — | — | 1 | 6.77 |
| CHEMBL1088447 | — | — | 1 | 6.68 |
| CHEMBL103410 | — | — | 1 | 5.96 |
| CHEMBL1082223 | — | — | 1 | 5.82 |
| CHEMBL1087679 | — | — | 1 | 5.80 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.70 |
| CHEMBL1082222 | — | — | 1 | 5.60 |
| CHEMBL1088425 | — | — | 1 | 5.54 |
| CHEMBL1087689 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35241 | DIMINAZENE | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1086746 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1088447 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL103410 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1082223 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1087679 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL140 | CURCUMIN | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1082222 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1088425 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1087689 | — | EC50 | = | 5600.0 | nM | 5.25 |