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Assay Detail

CHEMBL5368979

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against pentamidine resistant Trypanosoma brucei B48 incubated for 70 hrs by resazurin dye based assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei (CHEMBL612849)
Type ORGANISM
Organism Trypanosoma brucei

Publication

Synthesis and Biophysical and Biological Studies of <i>N</i>-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites.
Nué-Martinez JJ, Cisneros D, Moreno-Blázquez MDV, Fonseca-Berzal C, Manzano JI, Kraeutler D, Ungogo MA, Aloraini MA, Elati HAA, Ibáñez-Escribano A, Lagartera L, Herraiz T, Gamarro F, de Koning HP, Gómez-Barrio A, Dardonville C.
J Med Chem (2023) 66 : 13452 -13480
PubMed 37729094 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 29 5.29 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL35241 DIMINAZENE 2.0 1 7.92
CHEMBL55 PENTAMIDINE 4.0 1 6.96
CHEMBL5415696 1 6.80
CHEMBL5396668 1 6.46
CHEMBL5405513 1 6.16
CHEMBL5402608 1 5.76
CHEMBL5436238 1 5.74
CHEMBL5420686 1 5.71
CHEMBL5417618 1 5.66
CHEMBL5418014 1 5.53
CHEMBL5439900 1 5.40
CHEMBL5418641 1 5.30
CHEMBL5403847 1 5.24
CHEMBL5417039 1 5.16
CHEMBL5416121 1 5.12
CHEMBL5404100 1 4.97
CHEMBL5395180 1 4.94
CHEMBL5402794 1 4.90
CHEMBL5441079 1 4.83
CHEMBL5437728 1 4.80
CHEMBL5410436 1 4.62
CHEMBL5415718 1 4.55
CHEMBL5435713 1 4.43
CHEMBL5429716 1 4.32
CHEMBL5438251 1 4.30
CHEMBL5412472 1 4.24
CHEMBL5422257 1 4.16
CHEMBL5415937 1 4.09
CHEMBL5396609 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL35241 DIMINAZENE EC50 = 12.0 nM 7.92
CHEMBL55 PENTAMIDINE EC50 = 111.0 nM 6.96
CHEMBL5415696 EC50 = 160.0 nM 6.80
CHEMBL5396668 EC50 = 350.0 nM 6.46
CHEMBL5405513 EC50 = 690.0 nM 6.16
CHEMBL5402608 EC50 = 1730.0 nM 5.76
CHEMBL5436238 EC50 = 1810.0 nM 5.74
CHEMBL5420686 EC50 = 1930.0 nM 5.71
CHEMBL5417618 EC50 = 2200.0 nM 5.66
CHEMBL5418014 EC50 = 2930.0 nM 5.53
CHEMBL5439900 EC50 = 3960.0 nM 5.40
CHEMBL5418641 EC50 = 5000.0 nM 5.30
CHEMBL5403847 EC50 = 5750.0 nM 5.24
CHEMBL5417039 EC50 = 6900.0 nM 5.16
CHEMBL5416121 EC50 = 7600.0 nM 5.12
CHEMBL5404100 EC50 = 10770.0 nM 4.97
CHEMBL5395180 EC50 = 11600.0 nM 4.94
CHEMBL5402794 EC50 = 12500.0 nM 4.90
CHEMBL5441079 EC50 = 14800.0 nM 4.83
CHEMBL5437728 EC50 = 16000.0 nM 4.80
CHEMBL5410436 EC50 = 24000.0 nM 4.62
CHEMBL5415718 EC50 = 28100.0 nM 4.55
CHEMBL5435713 EC50 = 37500.0 nM 4.43
CHEMBL5429716 EC50 = 48400.0 nM 4.32
CHEMBL5438251 EC50 = 50100.0 nM 4.30
CHEMBL5412472 EC50 = 57400.0 nM 4.24
CHEMBL5422257 EC50 = 68800.0 nM 4.16
CHEMBL5415937 EC50 = 81900.0 nM 4.09
CHEMBL5396609 EC50 > 100000.0 nM -