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Compound Detail

CHEMBL5402608

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c1ccc2[nH]c(Nc3ccc4c(c3)Cc3cc(Nc5nc6ccccc6[nH]5)ccc3-4)nc2c1

Basic Information

ChEMBL ID CHEMBL5402608
Phase Preclinical
Structure Type MOL
InChI Key ZJQYKNPBQQJQIJ-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

428.5
MW (Da)
6.50
ALogP
4
HBA
4
HBD
81.4
PSA (Ų)
0.26
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H20N6
MW 428.50
Aromatic Rings 6
Heavy Atoms 33
NP-Likeness -0.63

Activity Summary

EC50 3 meas. best 5.76

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trypanosoma brucei
CHEMBL612849
EC50 5.76 5.685 1730.0 2
Trichomonas vaginalis
CHEMBL612884
EC50 4.48 4.48 33200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine