Acid-sensing ion channel 1/2 · PROTEIN FAMILY · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q6NXK8. Use UniProt Q6NXK8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6NXK8 as the stable identity anchor, then attach disease evidence before program review.
Acid-sensing ion channel 1
Review this target as Acid-sensing ion channel 1/2, mapped to UniProt Q6NXK8. ChEMBL maps the protein component as Acid-sensing ion channel 1. Sequence length is 526 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Acid-sensing ion channel 1/2 as ChEMBL target CHEMBL4523651, mapped to UniProt Q6NXK8. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Acid-sensing ion channel 1/2 is the right protein anchor across sources, using UniProt Q6NXK8 as the stable mapping.
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| Preferred Name | Acid-sensing ion channel 1/2 |
| Target Type | PROTEIN FAMILY |
| Organism | Mus musculus |
| UniProt | Q6NXK8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Acid-sensing ion channel 1 |
| UniProt Accession | Q6NXK8 |
| Component Type | Protein |
| Sequence Length | 526 aa |
Acid-sensing ion channel 1
Review this target as Acid-sensing ion channel 1/2, mapped to UniProt Q6NXK8. ChEMBL maps the protein component as Acid-sensing ion channel 1. Sequence length is 526 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4445209 | 5.07 | IC50 | 8500.0 | Preclinical |
| CHEMBL4518161 | 4.96 | IC50 | 10900.0 | Preclinical |
| CHEMBL4528810 | 4.95 | IC50 | 11300.0 | Preclinical |
| CHEMBL35241 | 4.34 | IC50 | 45200.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 4 | 4.8 |