Assay Detail
Functional
CHEMBL817915
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In vitro activity against bloodstream from trypomastigotes.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 8.52 |
| CHEMBL166618 | — | — | 1 | 4.68 |
| CHEMBL167202 | — | — | 1 | 4.62 |
| CHEMBL355685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35241 | DIMINAZENE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL166618 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL167202 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL355685 | — | IC50 | = | 110000.0 | nM | - |