Assay Detail
Functional
CHEMBL3998898
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-parasitic activity against bloodstream trypomastigote stage of wild-type Trypanosoma brucei brucei Lister 427 after 48 hrs by alamar blue based fluorescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.98 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477683 | PHENYLARSINE OXIDE | — | 1 | 8.96 |
| CHEMBL4099534 | — | — | 1 | 8.92 |
| CHEMBL4072631 | — | — | 1 | 8.89 |
| CHEMBL4098620 | — | — | 1 | 8.82 |
| CHEMBL4104322 | — | — | 1 | 8.74 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.55 |
| CHEMBL4061239 | — | — | 1 | 8.23 |
| CHEMBL4080586 | — | — | 1 | 8.05 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 7.19 |
| CHEMBL4083110 | — | — | 1 | 7.14 |
| CHEMBL4086675 | — | — | 1 | 7.00 |
| CHEMBL4078575 | — | — | 1 | 6.85 |
| CHEMBL4104576 | — | — | 1 | 6.85 |
| CHEMBL4096593 | — | — | 1 | 6.70 |
| CHEMBL4096176 | — | — | 1 | 6.48 |
| CHEMBL4086428 | — | — | 1 | 6.40 |
| CHEMBL4090897 | — | — | 1 | 4.84 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | — | 1 | 4.77 |
| CHEMBL4068891 | — | — | 1 | 4.50 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | — | 1 | 4.41 |
| CHEMBL4069905 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477683 | PHENYLARSINE OXIDE | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4099534 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4072631 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4098620 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4104322 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4061239 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4080586 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4083110 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4086675 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4078575 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4104576 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4096593 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4096176 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4086428 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4090897 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL328910 | 2,4-DIHYDROXYBENZOIC ACID | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4068891 | — | EC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL309339 | SALICYLHYDROXAMIC ACID | EC50 | = | 38700.0 | nM | 4.41 |
| CHEMBL4069905 | — | EC50 | = | 45700.0 | nM | 4.34 |