Assay Detail

CHEMBL3829364

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to wild type Bcl2 27-mer G-quadruplex DNA (unknown origin) by isothermal titration calorimetry

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Not specified
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities.

Wang C, Carter-Cooper B, Du Y, Zhou J, Saeed MA, Liu J, Guo M, Roembke B, Mikek C, Lewis EA, Lapidus RG, Sintim HO.
Eur J Med Chem (2016) 118 : 266 -275
PubMed 27132164 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	9.00	9.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL35241	DIMINAZENE	2.0	1	9.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL35241	DIMINAZENE	Kd	=	1.0	nM	9.00